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Rome to Venice: Italy in 10

Classic south-to-north run: Eternal City, Tuscan hills, Cinque Terre cliffs, Venetian canals. Heads up on Italian driving — ZTL (limited traffic zones) fines are brutal in city centers, so park outside the walls everywhere and walk in. Also book the Vatican, Uffizi, and Accademia (David) ahead or you'll burn half a day in line.


Route: Rome → Orvieto → Siena → San Gimignano → Florence → Pisa → Cinque Terre (Vernazza) → Verona → Venice → Burano
Primary area: Italy
✅ Current month (May) is in this region's prime season. France/Italy/Spain/Greece: May-Jun & Sep-Oct ideal. Jul-Aug 35°C+ + tourist crowds + August closures.
10days
29stops
875drive km
Money Savers
  1. 1Best swap-in: if you hate driving, do this entire route by train — Italy's Frecciarossa is faster than driving on every leg except Tuscany. Rent a car for just Day 3-5 and return it in Florence.
Heads Up

ZTL warning: every historic city center is a camera-enforced no-drive zone. Always park outside walls.

Book ahead: Vatican, Colosseum, Uffizi, Accademia, Duomo dome climb. Weeks in advance in summer.

Cash: small trattorias and some bacari are cash-only. Keep €50-100 on you.

1
Landing in Rome, easing in (walking day)
3 stops · 10m · 3km
2
Vatican day
3 stops · 35m · 9km
3
Pick up the car, drift into Umbria
3 stops · 3.5h · 230km
4
Tuscan hills to Florence
4 stops · 3h 59m · 242km
5
Florence Renaissance deep-dive
3 stops · 28m · 6km
6
Pisa lean-by, then the cliffs
3 stops · 2h 55m · 189km
7
Cinque Terre slow day
2 stops · 39m · 19km
8
Across the north to Venice
3 stops · 4h 48m · 401km
9
Venice proper
3 stops · 19m · 5km
10
Burano, then fly out
2 stops
Rome to Venice: Italy in 10 | Roadigo