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Classic south-to-north run: Eternal City, Tuscan hills, Cinque Terre cliffs, Venetian canals. Heads up on Italian driving — ZTL (limited traffic zones) fines are brutal in city centers, so park outside the walls everywhere and walk in. Also book the Vatican, Uffizi, and Accademia (David) ahead or you'll burn half a day in line.
ZTL warning: every historic city center is a camera-enforced no-drive zone. Always park outside walls.
Book ahead: Vatican, Colosseum, Uffizi, Accademia, Duomo dome climb. Weeks in advance in summer.
Cash: small trattorias and some bacari are cash-only. Keep €50-100 on you.
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